
Co-Principal Investigator
IMPACTT
+1 628 206-6480
1. Programmatic implementation of population-based colorectal cancer screening and follow-up of abnormal screening results. We embrace big data and technology to design, develop, and deliver economic and effective services for patients and health systems.
2. Use of human gut samples to study HIV, Covid-19, barrier function, systemic inflammation, inflammatory bowel disease, and microbiome. Approaches employed: organoid models, isolation of epithelial cells and lymphocytes, single cell, spatial transcriptomic analysis, microbial profiling, and blood-based profiling.
Publications
Multilevel intervention for follow-up of abnormal FIT in the safety-net: IMProving Adherence to Colonoscopy through Teams and Technology (IMPACTT).
Contemporary clinical trials
Tissue-based T cell activation and viral RNA persist for up to 2 years after SARS-CoV-2 infection.
Science translational medicine
Colorectal Cancer Screening: A Multicomponent Intervention to Increase Uptake in Patients Aged 45-49.
Journal of the American Board of Family Medicine : JABFM
Does Propofol Improve Polyp Detection during Colonoscopy? The Promise and Peril of Clinical Registry Data.
Anesthesiology
The effect of mailed outreach on FIT completion among patients aged 45-50 in a safety net healthcare system.
Cancer causes & control : CCC
Electronic coding for abnormal fecal immunochemical test is associated with increased colonoscopy completion.
The American journal of gastroenterology
Assessing the Impact of COVID-19 on IBD Outcomes Among Vulnerable Patient Populations in a Large Metropolitan Center.
Inflammatory bowel diseases
Intestinal Metaplasia Associated with Symptoms of Dyspepsia.
Research square
Delivering High-Quality, Efficient Gastroenterology Care to Vulnerable and Underserved Populations: Special Considerations and Possible Solutions.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Multimodal Molecular Imaging Reveals Tissue-Based T Cell Activation and Viral RNA Persistence for Up to 2 Years Following COVID-19.
medRxiv : the preprint server for health sciences
Implementation of a novel program to support colorectal cancer screening in a community health center consortium before and after the onset of COVID-19: a qualitative study of stakeholders' perspectives.
Implementation science communications
The human microbiome and gut-liver axis in people living with HIV.
Current HIV/AIDS reports
Effect of Mailed Fecal Immunochemical Test Outreach for Patients Newly Eligible for Colorectal Cancer Screening.
Digestive diseases and sciences
Durability of FIT Screening After Cessation of a Screening Outreach Intervention.
Digestive diseases and sciences
LOXL-2 and TNC-C are markers of liver fibrogenesis in HCV/HIV-, HIV- and HCV-infected patients.
Biomarkers in medicine
Extent of Follow-Up on Abnormal Cancer Screening in Multiple California Public Hospital Systems: A Retrospective Review.
Journal of general internal medicine
Determinants of Colorectal Cancer Screening among South Asian Americans.
Journal of Asian health
From Cancer Epidemiology to Policy and Practice: the Role of a Comprehensive Cancer Center.
Current epidemiology reports
Multiomic Analysis of the Gut Microbiome in Psoriasis Reveals Distinct Host?Microbe Associations.
JID innovations : skin science from molecules to population health
A Root Cause Analysis of Barriers to Timely Colonoscopy in California Safety-Net Health Systems.
Journal of patient safety
Asian American/Pacific Islander and Hispanic Ethnic Enclaves, Neighborhood Socioeconomic Status, and Hepatocellular Carcinoma Incidence in California: An Update.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Gag p24 Is a Marker of Human Immunodeficiency Virus Expression in Tissues and Correlates With Immune Response.
The Journal of infectious diseases
Dual targeting of lymphocyte homing and retention through α4β7 and αEβ7 inhibition in inflammatory bowel disease.
Cell reports. Medicine
Increased Colorectal Cancer Screening Sustained with Mailed Fecal Immunochemical Test Outreach.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
LINGO3 regulates mucosal tissue regeneration and promotes TFF2 dependent recovery from colitis.
Scandinavian journal of gastroenterology
A Methodology to Generate Longitudinally Updated Acute-On-Chronic Liver Failure Prognostication Scores From Electronic Health Record Data.
Hepatology communications
Selection of patients for large mailed fecal immunochemical test colorectal cancer screening outreach programs: A systematic review.
Journal of medical screening
Colorectal Cancer Screening and COVID-19.
The American journal of gastroenterology
Shared Mechanisms Govern HIV Transcriptional Suppression in Circulating CD103+ and Gut CD4+ T Cells.
Journal of virology
Mechanistic differences underlying HIV latency in the gut and blood contribute to differential responses to latency-reversing agents.
AIDS (London, England)
Advanced Notification Calls Prior to Mailed Fecal Immunochemical Test in Previously Screened Patients: a Randomized Controlled Trial.
Journal of general internal medicine
Changes in gastrointestinal microbial communities influence HIV-specific CD8+ T-cell responsiveness to immune checkpoint blockade.
AIDS (London, England)
Obesity and metabolic outcomes in a safety-net health system.
Biodemography and social biology
Colorectal Cancer Screening and Prevention in the COVID-19 Era.
JAMA health forum
Antiretroviral Therapy Concentrations Differ in Gut vs. Lymph Node Tissues and Are Associated With HIV Viral Transcription by a Novel RT-ddPCR Assay.
Journal of acquired immune deficiency syndromes (1999)
Standardized Workflows Improve Colonoscopy Follow-Up After Abnormal Fecal Immunochemical Tests in a Safety-Net System.
Digestive diseases and sciences
Effectiveness and Cost of Organized Outreach for Colorectal Cancer Screening: A Randomized, Controlled Trial.
Journal of the National Cancer Institute
Human Immunodeficiency Virus (HIV)-Infected CCR6+ Rectal CD4+ T Cells and HIV Persistence On Antiretroviral Therapy.
The Journal of infectious diseases
HIV-1-induced cytokines deplete homeostatic innate lymphoid cells and expand TCF7-dependent memory NK cells.
Nature immunology
Impact of Antiretroviral Therapy Duration on HIV-1 Infection of T Cells within Anatomic Sites.
Journal of virology
Disparities in Hepatocellular Carcinoma Incidence in California: An Update.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths.
Nature communications
Fecal Microbiota Transplantation in Pouchitis: Clinical, Endoscopic, Histologic, and Microbiota Results from a Pilot Study.
Digestive diseases and sciences
HIV and the Gut Microbiota: Composition, Consequences, and Avenues for Amelioration.
Current HIV/AIDS reports
CD32-RNA Co-localizes with HIV-RNA in CD3+ Cells Found within Gut Tissues from Viremic and ART-Suppressed Individuals.
Pathogens & immunity
Serum Bovine Immunoglobulins Improve Inflammation and Gut Barrier Function in Persons with HIV and Enteropathy on Suppressive ART.
Pathogens & immunity
Fecal microbiota transplant for Crohn disease: A study evaluating safety, efficacy, and microbiome profile.
United European gastroenterology journal
Increased mucosal neutrophil survival is associated with altered microbiota in HIV infection.
PLoS pathogens
Low Literacy Level Instructions and Reminder Calls Improve Patient Handling of Fecal Immunochemical Test Samples.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Population health interventions to improve colorectal cancer screening by fecal immunochemical tests: A systematic review.
Preventive medicine
Macrophage Activation Marker Soluble CD163 Is a Dynamic Marker of Liver Fibrogenesis in Human Immunodeficiency Virus/Hepatitis C Virus Coinfection.
The Journal of infectious diseases
Colorectal Cancer Incidence Trends by Age, Stage, and Racial/Ethnic Group in California, 1990-2014.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Race/ethnicity is an independent risk factor for autoimmune hepatitis among the San Francisco underserved.
Autoimmunity
Yield of Colonoscopy After a Positive Result From a Fecal Immunochemical Test OC-Light.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
A20 upregulation during treated HIV disease is associated with intestinal epithelial cell recovery and function.
PLoS pathogens
Increased HIV-1 transcriptional activity and infectious burden in peripheral blood and gut-associated CD4+ T cells expressing CD30.
PLoS pathogens
Hospitalizations for Autoimmune Hepatitis Disproportionately Affect Black and Latino Americans.
The American journal of gastroenterology
Differential Expression of CD8+ T Cell Cytotoxic Effector Molecules in Blood and Gastrointestinal Mucosa in HIV-1 Infection.
Journal of immunology (Baltimore, Md. : 1950)
Missed Opportunities in Colorectal Cancer Prevention in Patients With Inadequate Bowel Preparations.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Colorectal Cancer Screening Among South Asians: Focus Group Findings on Attitudes, Knowledge, Barriers and Facilitators.
Journal of Health Care for the Poor and Underserved
The San Francisco Cancer Initiative: A Community Effort To Reduce The Population Burden Of Cancer.
Health affairs (Project Hope)
Risk factors for postpolypectomy bleeding in patients receiving anticoagulation or antiplatelet medications.
Gastrointestinal endoscopy
Detection of HIV-1-specific gastrointestinal tissue resident CD8+ T-cells in chronic infection.
Mucosal immunology
An Optimized and Validated Method for Isolation and Characterization of Lymphocytes from HIV+ Human Gut Biopsies.
AIDS research and human retroviruses
Evaluation of oral serum-derived bovine immunoglobulins in HIV-infected patients with chronic idiopathic diarrhea.
HIV clinical trials
A Randomized Controlled Trial of Lisinopril to Decrease Lymphoid Fibrosis in Antiretroviral-Treated, HIV-infected Individuals.
Pathogens & immunity
Circulating LOXL2 Levels Reflect Severity of Intestinal Fibrosis and GALT CD4+ T Lymphocyte Depletion in Treated HIV Infection.
Pathogens & immunity
Human Immunodeficiency Virus Persistence and T-Cell Activation in Blood, Rectal, and Lymph Node Tissue in Human Immunodeficiency Virus-Infected Individuals Receiving Suppressive Antiretroviral Therapy.
The Journal of infectious diseases
Replication of CMV in the gut of HIV-infected individuals and epithelial barrier dysfunction.
PLoS pathogens
Urgent colonoscopy in patients with lower GI bleeding: a systematic review and meta-analysis.
Gastrointestinal endoscopy
Inadequate Utilization of Diagnostic Colonoscopy Following Abnormal FIT Results in an Integrated Safety-Net System.
The American journal of gastroenterology
Predominance of weakly cytotoxic, T-betLowEomesNeg CD8+ T-cells in human gastrointestinal mucosa: implications for HIV infection.
Mucosal immunology
Bacteroides are associated with GALT iNKT cell function and reduction of microbial translocation in HIV-1 infection.
Mucosal immunology
Protective association of colonoscopy against proximal and distal colon cancer and patterns in interval cancer.
Gastrointestinal endoscopy
Longitudinal Genetic Characterization Reveals That Cell Proliferation Maintains a Persistent HIV Type 1 DNA Pool During Effective HIV Therapy.
The Journal of infectious diseases
Gut epithelial barrier and systemic inflammation during chronic HIV infection.
AIDS (London, England)
Lymphoid fibrosis occurs in long-term nonprogressors and persists with antiretroviral therapy but may be reversible with curative interventions.
The Journal of infectious diseases
The CD8⁺ memory stem T cell (T(SCM)) subset is associated with improved prognosis in chronic HIV-1 infection.
Journal of virology
Challenges and possible solutions to colorectal cancer screening for the underserved.
Journal of the National Cancer Institute
Non-physician performance of lower and upper endoscopy: a systematic review and meta-analysis.
Endoscopy
Adverse events in older patients undergoing ERCP: a systematic review and meta-analysis.
Endoscopy international open
Discordance between peripheral and colonic markers of inflammation during suppressive ART.
Journal of acquired immune deficiency syndromes (1999)
A comparison of methods for measuring rectal HIV levels suggests that HIV DNA resides in cells other than CD4+ T cells, including myeloid cells.
AIDS (London, England)
Commentary: Towards an effective and safe treatment of small intestine bacterial overgrowth - Authors' reply.
Alimentary pharmacology & therapeutics
The HIV-1 reservoir in eight patients on long-term suppressive antiretroviral therapy is stable with few genetic changes over time.
Proceedings of the National Academy of Sciences of the United States of America
Helicobacter pylori: evidence-based review with a focus on immigrant populations.
Journal of general internal medicine
Comparison of HIV DNA and RNA in gut-associated lymphoid tissue of HIV-infected controllers and noncontrollers.
AIDS (London, England)
Meta-analysis: antibiotic therapy for small intestinal bacterial overgrowth.
Alimentary pharmacology & therapeutics
Dysbiosis of the gut microbiota is associated with HIV disease progression and tryptophan catabolism.
Science translational medicine
Late presentation of colorectal cancer in a vulnerable population.
The American journal of gastroenterology
Short communication: HIV+ viremic slow progressors maintain low regulatory T cell numbers in rectal mucosa but exhibit high T cell activation.
AIDS research and human retroviruses
Adherence to colorectal cancer screening: a randomized clinical trial of competing strategies.
Archives of internal medicine
Adverse events in older patients undergoing colonoscopy: a systematic review and meta-analysis.
Gastrointestinal endoscopy
Prevalence of gastric cancer versus colorectal cancer in Asians with a positive fecal occult blood test.
Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology
Increased frequency of regulatory T cells accompanies increased immune activation in rectal mucosae of HIV-positive noncontrollers.
Journal of virology
Moderate ascites identifies patients with low model for end-stage liver disease scores awaiting liver transplantation who have a high mortality risk.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Ascites improves upon [corrected] serum sodium plus [corrected] model for end-stage liver disease (MELD) for predicting mortality in patients with advanced liver disease.
Alimentary pharmacology & therapeutics
New model for end stage liver disease improves prognostic capability after transjugular intrahepatic portosystemic shunt.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Understanding liver health using the National Center for Health Statistics.
Digestive diseases and sciences
A cost-utility analysis of ablative therapy for Barrett's esophagus.
Gastroenterology
Management of obscure occult gastrointestinal bleeding: a cost-minimization analysis.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Actinomycosis mimicking a pancreatic head neoplasm diagnosed by EUS-guided FNA.
Gastrointestinal endoscopy
A cost-identification analysis of screening and surveillance of hepatitis C infection in a prospective cohort of dialysis patients.
Digestive diseases and sciences
Will virtual colonoscopy replace optical colonoscopy for colorectal cancer screening?
Gastroenterology
Proton pump inhibitors and hip fracture: cause for alarm?
Gastroenterology
Determination of the three-dimensional, solution-phase structure of the macrolide antibiotic oxolide in CD2Cl2 and D2O from NMR constraints.
Magnetic resonance in chemistry : MRC
Constitutive activation of Stat3 signaling pathway in human colorectal carcinoma.
World journal of gastroenterology
Hepatitis C virus is independently associated with increased insulin resistance after liver transplantation.
Transplantation
Critical elements of the immunoglobulin heavy chain gene enhancers for deregulated expression of bcl-2.
Cancer research
Spontaneous resolution of chronic hepatitis C virus disease after withdrawal of immunosuppression.
Gastroenterology
Promoter structure and cell cycle dependent expression of the human methylpurine-DNA glycosylase gene.
Mutation research
Partial functional deficiency of E160D flap endonuclease-1 mutant in vitro and in vivo is due to defective cleavage of DNA substrates.
The Journal of biological chemistry